The U.S. Department of Labor selected John to represent the United States in 2001 at the "Violence as a Workplace Risk Conference" held in Montreal, Canada. The conference is a joint effort by the United States, Canada and Mexico through the North American Agreement on Labor Cooperation (NAALC), the NAFTA labor side agreement.

From 2002 - 2006 Dr. Byrnes partnered with Aon Corporation to form Aon Aggression Management. As part of Aon's Crisis Management Practice, John worked with many Fortune 200 companies, and the Giuliani Partnership headed by the former NYC Mayor Rudy Giuliani. During this time, John met with DARPA, DHS’s Science and Technology Directorate and worked with the U.S. Army's Night Vision & Electronic Sensors Directorate developing methods and technologies for "Badguyology."

Dr. Byrnes was the keynote speaker at the first Protective Security Conference (ProSecCon) in 2008 sponsored by Walmart, Inc. The world’s leading executive protective security professionals were in attendance representing such organizations as the Bill and Melinda Gates Foundation, The Coca-Cola Company, Cisco Systems, Inc., Microsoft, Dell, Amazon, Kellogg Company, Walmart, Kissinger & Associates, Overseas Advisory Council (OSAC), and many more.

From 2007 - 2010 he led the creation of the Campus Aggression Prevention System (CAPS) for colleges and universities. John conducted training for individuals from more than 500 campuses through The National Center for Higher Education Risk Management, Ltd. (NCHERM) and the National Behavioral Intervention Team Association (NaBITA). In 2010 John added the Meter of Emerging Aggression (MEA) to CAPS and further expanded it incorporating all of the knowledge and training he had developed for preventing aggression in the workplace. This updated approach was renamed the Critical Aggression Prevention System (CAPS). In 2013, after two years of application, CAPS was scientifically validated by Eastern Kentucky University's Student Assistance and Intervention Team (SAIT) members.

The following are some of Dr. Byrnes's noteworthy accomplishments and honors over the years:           

• Proud Navy Veteran (USS Nautilus SSN 571 | First Nuclear Powered Submarine).
• The Center for Aggression Management, Inc. is a VA Certified Veteran Owned Small Business (VOSB) 
• The Center for Aggression Management, Inc. is a certified member of the National Veteran Owned Business Association (NaVOBA)     
• Conducted CAPS Executive Protection training for legendary Bob Duggan and his Executive Security International (ESI) and was keynote speaker at his annual conference (2007-2011). 
• Conducted Insider Threat Prevention Training for the U.S. Army Special Operations Command, Terrorism Division in 2016.
• Authored the NaBITA Threat Assessment Tool, now being used by behavior intervention teams in more than 177 college and university campuses.
• Interviewed by various major news outlets on the topic of violence in workplaces, on campuses, in churches, and/or schools.
• Presented at more than 100 conferences addressing violence in workplaces, on campuses, in churches, and/or schools.     
• Awarded a Doctorate of Humanities Honoris Causa for his discovery and development of Aggression Management in 2000.
• Received a Fellowship with the American College of Healthcare Trustees in 2022.